Solid-state O-17 NMR in Carbohydrates

Solid-state 17O NMR in Carbohydrates

T. Sefzik, J. B. Houseknecht, T. M. Clark, S. Prasad, T. L. Lowary, Z. Gan, and P. J. Grandinetti
055 - J. Magn. Reson., 185 (2), 326-330 (2007)

Abstract

Solid-state $^{17}$O magic-angle spinning nuclear magnetic resonance measurements at 19.5 Tesla were performed on $^{17}$O-enriched methyl $\alpha$-D-galactopyranoside (4-$^{17}$O), methyl $\beta$-D-Glucopyranoside (2-$^{17}$O), methyl $\alpha$-D-Glucopyranoside (4-$^{17}$O), methyl $\alpha$-D-Glucopyranoside (6-$^{17}$O), and $\alpha$-D-Glucopyranosyl ($1$$\rightarrow$$6$) $\alpha$-D-Glucopyranoside (6-$^{17}$O). The $^{17}$O quadrupolar coupling constants and asymmetry parameters measured can be predicted with a model based entirely on the first-coordination sphere around oxygen. For the hydroxyl sites observed in the methyl glucosides the quadrupolar coupling parameters are nearly identical, within 10\%, as predicted, given their nearly identical first coordination sphere structures.