Objective and Clientele:

This course is an introduction to nuclear magnetic resonance for students who seek expertise in the fundamentals of nuclear magnetic resonance. Lectures cover theory, instrumentation, and applications in the physical sciences, engineering, and health-related fields.

Prerequisites:

Undergraduate physics (phys. 122 or equivalent)

Course Outline:

Overview

Precessing Tops and the Faraday Detector, The Zeeman Interaction, The Chemical Shift Interaction, Magnetic Resonance, Coherence, Relaxation, Inhomogeneous magnetic fields and T₂^∗

The Bloch Equations

Free Precession, RF Pulses, Bloch Decay Experiment.

The Fourier Transform

Absorption and Dispersion mode lineshapes, Phase Corrections.

Limitations of the Bloch Equations

Equations Dipolar Couplings, J Couplings, Nuclear Electric Quadrupole Couplings, Spin Decoupling.

Inside the NMR Spectrometer

Magnetic field homogeneity, shimming, NMR probe design, Signal averaging.

Measuring Relaxation Times

Saturation Recovery, Inversion Recovery, Spin Echo, Echo Train Acquisition.

Coherence Transfer Pathways

Measuring Translational Diffusion Coefficients

Interpreting Relaxation Times

Time correlation and Spectral Density Functions, Relaxation via Dipolar Couplings, Steady- State Overhauser Effect, Quadrupolar Relaxation, Nuclear Shielding Relaxation.

Measuring Chemical Exchange

Modified Bloch Equations.

Multi-dimensional NMR in liquids

2D Exchange, 2D NOESY, transient nOe’s, COSY, ROESY, HSQC, TOCSY, HMQC, HMBC, INEPT, INADEQUATE, etc...

Magnetic Resonance Imaging

Basic principles, k-space, Echo-Planar Imaging.

NMR in the Solid State

Single crystals, Polycrystalline Solids, Magic-Angle Spinning, Cross-Polarization, Spinning Sidebands.