Chem 7160: Magnetic Resonance Spectroscopy


Objective and Clientele:

This course is an introduction to nuclear magnetic resonance for students who seek expertise in the fundamentals of nuclear magnetic resonance. Lectures cover theory, instrumentation, and applications in the physical sciences, engineering, and health-related fields.


Undergraduate physics (phys. 122 or equivalent)

Course Outline:

Precessing Tops and the Faraday Detector, The Zeeman Interaction, The Chemical Shift Interaction, Magnetic Resonance, Coherence, Relaxation, Inhomogeneous magnetic fields and T2
The Bloch Equations
Free Precession, RF Pulses, Bloch Decay Experiment.
The Fourier Transform
Absorption and Dispersion mode lineshapes, Phase Corrections.
Limitations of the Bloch Equations
Equations Dipolar Couplings, J Couplings, Nuclear Electric Quadrupole Couplings, Spin Decoupling.
Inside the NMR Spectrometer
Magnetic field homogeneity, shimming, NMR probe design, Signal averaging.
Measuring Relaxation Times
Saturation Recovery, Inversion Recovery, Spin Echo, Echo Train Acquisition.
Coherence Transfer Pathways
Measuring Translational Diffusion Coefficients
Interpreting Relaxation Times
Time correlation and Spectral Density Functions, Relaxation via Dipolar Couplings, Steady- State Overhauser Effect, Quadrupolar Relaxation, Nuclear Shielding Relaxation.
Measuring Chemical Exchange
Modified Bloch Equations.
Multi-dimensional NMR in liquids
2D Exchange, 2D NOESY, transient nOe’s, COSY, ROESY, HSQC, TOCSY, HMQC, HMBC, INEPT, INADEQUATE, etc...
Magnetic Resonance Imaging
Basic principles, k-space, Echo-Planar Imaging.
NMR in the Solid State
Single crystals, Polycrystalline Solids, Magic-Angle Spinning, Cross-Polarization, Spinning Sidebands.

All students with documented disabilities, who need accommodations, should see the instructor privately to schedule an appointment as early in the quarter as possible. If your disability requires materials in alternative format, please contact the Office for Disability Services at 292-3307, Room 150 Pomerene Hall.


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